ABSTRACT
Objective To investigate the expression pattern of linc00346 and E2F2, and its prognostic value on liver cancer. Methods Gene expression profile data of patients with liver cancer was downloaded from the cancer genome atlas (TCGA) database. Paired t test was used to evaluate the differential expression of linc00346 and E2F2 from tissues and matched adjacent normal tissues. Co-expression analysis of linc00346 and E2F2 was performed using Pearson correlation. Log-Rank test and Cox proportional hazards regression were used to estimate prognostic value of linc00346 and E2F2. Results linc00346 and E2F2 expression were upregulated in liver cancer tissue specimens (all P＜0.05), and fold change was 2.24 and 3.72, respectively. Pearson coefficient was 0.20 (P＜0.001). Patient with linc00346 and E2F2 high expression had a 1.77 (95 % CI: 1.23-2.55) and 2.19 (95 % CI: 1.51-3.17) times higher hazard of death than those with linc00346 and E2F2 low expression, respectively. However, only E2F2 was significantly associated with the prognosis of liver cancer in multiple Cox regression. Conclusions linc00346 and E2F2 expressions are upregulated in liver cancer tissues, and patients with linc00346 and E2F2 high expressions has poor prognosis. It is of great significance to discover linc00346 and E2F2 as a novel therapeutic target for liver cancer.
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the prevalence and differences between gender and grades of suicide ideation among middle school students in China from 2000 to 2012 so as to provide basis for suicide prevention among middle school students.</p><p><b>METHODS</b>Electronic search strategy was carried out, using PubMed, Wanfang Database, VIP Database, China National Knowledge Infrastructure (CNKI) and CBM to collect data on suicide ideation among middle school students. Fixed effects model or random effects model was employed according to statistical tests for the homogeneity. Publication bias was assessed by rank correlation test.</p><p><b>RESULTS</b>40 papers were included for meta-analysis, with a total sample size of 320 375. The combined prevalence of suicide ideation was 17.99% (95%CI: 16.59% - 19.49%). Prevalence rates of suicide ideation were stratified by factors as gender and grade at school. Pooled prevalence rates on suicide ideation were as follows: 14.71% (95%CI: 13.42% - 16.11%) and 19.92% (95%CI: 19.30% - 21.64%), P < 0.05 for boys and girls;16.94% (95%CI: 15.35% - 18.66%) and 19.01% (95%CI: 17.23% - 20.93%), P < 0.05 for senior or junior high school students, respectively.</p><p><b>CONCLUSION</b>There were differences in the prevalence of suicide ideation among middle school students between genders and grades in China.</p>